"No route to host (#10065 in TryToSend failed)"

IF you are not using the built in card processing and you are getting "No route to host (#10065 in TryToSend failed)" Try checking the STARTUP folder for Chargepath Client. If present, delete it.

Did you install Chargepath Server? You can remove it from the add/remove programs list.

Open Office Manager and choose "Setup credit card, gift card and loyalty options...".  Make sure the checkbox named  Use Credit Card Server..." is not checked.  ALSO, make sure "Manually close my credit card batches..." is not checked.